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| 23:00 | Universidad Catolica-EQU | 0 0x0 0 | Aucas-ECU | 56 | 25 | 19 | 1.70 | 3.76 | 4.80 |  | | 21:30 | Junior-COL | 0 2x2 2 | America Cali-COL | 37 | 30 | 33 | 2.55 | 3.11 | 2.83 | | | 21:30 | Deportivo La Guaira | 0 0x2 1 | Caracas FC-VEN | 35 | 31 | 34 | 2.66 | 3.02 | 2.77 | | | 21:30 | Atletico Grau-PER | 0 0x0 0 | Cusco FC-PER | 49 | 27 | 24 | 1.91 | 3.50 | 3.90 | | | 19:00 | Guarani-PAR | 1 2x0 0 | 2 De Mayo-PAR | 45 | 30 | 25 | 2.08 | 3.09 | 3.89 | | | 19:00 | Cerro Largo-URU | 2 2x2 0 | Danubio-URU | 35 | 32 | 33 | 2.72 | 2.95 | 2.77 | |
| 23:00 | Mushuc Ruma-ECU | 1 2x1 1 | Orense-ECU | 49 | 28 | 23 | 1.94 | 3.34 | 3.98 | | | 21:30 | Once Caldas-COL | 0 1x0 0 | Millonarios-COL | 29 | 32 | 39 | 3.20 | 2.90 | 2.43 | | | 19:00 | Union Espanola-CHI | 2 2x2 1 | Everton-CHI | 35 | 28 | 37 | 2.67 | 3.29 | 2.56 | | | 19:00 | Racing Club-URU | 0 0x0 0 | Wanderers-URU | 43 | 30 | 27 | 2.21 | 3.18 | 3.38 | | | 19:00 | Puerto Cabello-VEN | 0 3x0 0 | Metropolitanos-VEN | 40 | 31 | 29 | 2.34 | 3.03 | 3.25 | | | 19:00 | Aurora-BOL | 0 0x1 0 | San Jose-BOL | 57 | 24 | 19 | 1.64 | 3.89 | 4.97 | |
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