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| 14:30 | Osasuna | x | Mallorca | 35 | 31 | 34 | 2.74 | 3.07 | 2.89 |  |
| 16:00 | Tottenham | x | Manchester City | 14 | 17 | 69 | 6.92 | 5.74 | 1.40 | |
| 16:30 | Real Madrid | x | Alaves | 76 | 16 | 08 | 1.28 | 6.11 | 10.90 | | | 17:00 | Girona | x | Villarreal | 53 | 22 | 25 | 1.81 | 4.36 | 3.91 | |
| 19:00 | LDU Quito-ECU | x | Junior-COL | 62 | 23 | 15 | 1.53 | 4.14 | 5.92 | | | 19:00 | Penarol-URU | x | Atletico/MG-BRA | 32 | 30 | 38 | 2.96 | 3.14 | 2.46 | | | 19:00 | Talleres-ARG | x | Cobresal-CHI | 78 | 15 | 07 | 1.22 | 6.19 | 12.82 | |
| 19:00 | Racing Club-URU | x | Nacional Asuncion-PAR | 53 | 27 | 20 | 1.78 | 3.46 | 4.49 | |
| 19:00 | Avai/SC | x | CRB/AL | 39 | 31 | 30 | 2.40 | 2.98 | 3.19 | | | 19:00 | Vila Nova/GO | x | Novorizontino/SP | 41 | 31 | 28 | 2.32 | 3.05 | 3.27 | |
| 21:00 | Defensa y Justicia-ARG | x | Independiente Medellin-COL | 45 | 28 | 27 | 2.08 | 3.30 | 3.45 | | | 21:00 | Sportivo Ameliano-PAR | x | Rayo Zuliano-VEN | 87 | 10 | 03 | 1.07 | 9.27 | 30.73 | |
| 21:30 | River Plate-ARG | x | Libertad-PAR | 70 | 19 | 11 | 1.35 | 4.88 | 8.35 | |
| 21:30 | Corinthians/SP-BRA | x | Argentinos Juniors-ARG | 55 | 27 | 18 | 1.70 | 3.36 | 5.08 | |
| 21:30 | Botafogo/SP | x | Chapecoense/SC | 46 | 30 | 24 | 2.06 | 3.11 | 3.87 | | | 21:30 | Coritiba/PR | x | Guarani/SP | 57 | 27 | 16 | 1.64 | 3.50 | 5.76 | |
| 23:00 | Millonarios-COL | x | Palestino-CHI | 65 | 22 | 13 | 1.45 | 4.17 | 7.30 | |
| 23:00 | Nacional Potosi-BOL | x | Sportivo Trinidense-PAR | 76 | 15 | 09 | 1.22 | 6.31 | 9.92 | |
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