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| 16:00 | Paris St Germain-FRA | x | Borussia Dortmund-GER | 63 | 21 | 16 | 1.52 | 4.59 | 5.84 |  |
| 19:00 | Caracas FC-VEN | x | Penarol-URU | 22 | 27 | 51 | 4.32 | 3.44 | 1.84 | | | 19:00 | Rosario Central-ARG | x | Atletico/MG-BRA | 32 | 30 | 38 | 2.90 | 3.14 | 2.48 | |
| 19:00 | Nacional Asuncion-PAR | x | Corinthians/SP-BRA | 26 | 28 | 46 | 3.52 | 3.25 | 2.02 | | | 19:00 | Racing Club-URU | x | Argentinos Juniors-ARG | 26 | 29 | 45 | 3.58 | 3.14 | 2.05 | |
| 21:00 | Deportivo Tachira-VEN | x | Libertad-PAR | 24 | 27 | 49 | 3.96 | 3.43 | 1.91 | | | 21:00 | Nacional-URG | x | River Plate-ARG | 26 | 27 | 47 | 3.59 | 3.51 | 1.98 | | | 21:00 | Palestino-CHI | x | Flamengo/RJ-BRA | 15 | 22 | 63 | 6.01 | 4.30 | 1.49 | |
| 21:00 | Cesar Vallejo-PER | x | Independiente Medellin-COL | 31 | 29 | 40 | 2.90 | 3.24 | 2.33 | | | 21:00 | Real Tomayapo-BOL | x | Internacional/RS-BRA | 18 | 22 | 60 | 5.04 | 4.13 | 1.55 | |
| 21:00 | Botafogo/SP | x | Mirassol/SP | 32 | 32 | 36 | 2.86 | 2.94 | 2.60 | |
| 21:30 | Alianza Petrolera-COL | x | Cruzeiro/MG-BRA | 20 | 25 | 55 | 4.52 | 3.71 | 1.69 | | | 21:30 | Sportivo Ameliano-PAR | x | Danubio-URU | 39 | 28 | 33 | 2.34 | 3.27 | 2.81 | |
| 23:00 | Universitario-PER | x | Junior-COL | 43 | 29 | 28 | 2.20 | 3.28 | 3.28 | |
| 23:00 | Always Ready-BOL | x | Defensa y Justicia-ARG | 66 | 21 | 13 | 1.40 | 4.35 | 7.15 | |
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