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| 10:00 | Ural | x | Rostov | 37 | 29 | 34 | 2.62 | 3.23 | 2.79 |  | | 12:15 | Fakel Voronezh | x | Krylya Sovetov | 38 | 31 | 31 | 2.54 | 3.07 | 3.05 | |
| 13:45 | Heerenveen | x | PSV Eindhoven | 12 | 18 | 70 | 7.25 | 5.43 | 1.37 | |
| 14:30 | Akhmat Grozny | x | Sochi | 42 | 28 | 30 | 2.26 | 3.37 | 3.24 | | | 14:30 | CSKA Moscow | x | Spartak Moscow | 38 | 26 | 36 | 2.53 | 3.60 | 2.66 | |
| 15:00 | Udinese | x | Roma | 20 | 56 | 24 | 4.89 | 1.75 | 4.17 | |
| 15:30 | Antwerp | x | USt Gilloise | 32 | 28 | 40 | 3.00 | 3.36 | 2.36 | |
| 16:00 | Brighton | x | Manchester City | 14 | 20 | 66 | 6.77 | 4.92 | 1.46 | |
| 16:00 | Go Ahed Eagles | x | Feyenoord | 17 | 20 | 63 | 5.72 | 4.71 | 1.50 | |
| 19:00 | Cerro Porteno-PAR | x | Fluminense/RJ-BRA | 31 | 29 | 40 | 3.01 | 3.27 | 2.38 | | | 19:00 | Cobresal-CHI | x | Talleres-ARG | 24 | 28 | 48 | 3.93 | 3.39 | 1.97 | |
| 19:00 | Metropolitanos-VEN | x | Lanus-ARG | 18 | 25 | 57 | 5.24 | 3.70 | 1.63 | | | 19:00 | Nacional Asuncion-PAR | x | Racing Club-ARG | 44 | 29 | 27 | 2.14 | 3.20 | 3.42 | |
| 21:00 | Barcelona-ECU | x | Sao Paulo/SP-BRA | 27 | 29 | 44 | 3.52 | 3.32 | 2.16 | | | 21:00 | Palestino-CHI | x | Millonarios-COL | 34 | 30 | 36 | 2.79 | 3.12 | 2.62 | |
| 21:00 | Always Ready-BOL | x | Cesar Vallejo-PER | 71 | 19 | 10 | 1.31 | 4.90 | 9.64 | | | 21:00 | Fortaleza/CE-BRA | x | Boca Juniors-ARG | 47 | 29 | 24 | 2.02 | 3.26 | 3.81 | | | 23:00 | Delfin-ECU | x | Internacional/RS-BRA | 21 | 26 | 53 | 4.59 | 3.53 | 1.76 | | | 23:00 | Independiente Medellin-COL | x | Defensa y Justicia-ARG | 41 | 29 | 30 | 2.27 | 3.16 | 3.16 | |
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